A Randomized, Placebo-Controlled Study of the Safety, Tolerability, and Effect on Endothelial Function, as Measured by Flow-Mediated Dilatation, of RO4607381 in Patients With Coronary Heart Disease (CHD) or CHD Risk Equivalents - dal-VESSEL

Description:

Despite multiple attempts, no pharmacological agent thus far has been successful in increasing high-density lipoprotein (HDL) while reducing coronary events. Dalcetrapib is a cholesteryl ester transfer protein (CETP) inhibitor that has not shown off-target effects such as blood pressure (BP) elevation (noted with torcetrapib, another CETP inhibitor in the ILLUSTRATE and ILLUMINATE trials) in early trials. The current trial was a phase II trial designed to assess the efficacy and safety of...