An Educational Program

Program Directors:

Peter P. Liu, M.D., F.R.C.P.(C.), F.A.C.C.
Heart and Stroke/Polo Chair Professor of Medicine; Director, Heart and Stroke/ Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto and Toronto General Hospital/ University Health Network Toronto

John D. Parker, M.D., F.R.C.P.(C.), F.A.C.C.
Pfizer Chair in Cardiovascular Research, Professor of Medicine and Pharmacology, University of Toronto; Head Division of Cardiology, UHN and Mount Sinai Hospitals Toronto

FACULTY:

University of Toronto Faculty

Peter H. Backx, D.V.M., Ph.D.
Professor, Departments of Physiology and Medicine, University of Toronto

Diego H. Delgado, M.D.
Assistant Professor, Department of Medicine, University of Toronto; Division of Cardiology, Heart Failure and Transplant Program, Toronto General Hospital/UHN

Paul Dorian, M.D., M.Sc., F.R.C.P.(C.)
Professor of Medicine, University of Toronto; Director, Electrophysiology Service, Division of Cardiology, St. Michael’s Hospital

Ren-Ke Li, M.D., Ph.D.
Professor, Department of Surgery, University of Toronto; Senior Scientist, Toronto General Research Institute, UHN

Susanna S. S. Mak, M.D., Ph.D., F.R.C.P.(C.),
Assistant Professor of Medicine, University of Toronto; Attending Cardiologist, Mount Sinai Hospital

Gordon W. Moe, M.D., F.R.C.P.(C.), F.A.C.C.
Associate Professor, Division of Cardiology, Department of Medicine; Attending Cardiologist, St. Michael’s Hospital

Kumaraswamy Nanthakumar, M.D., F.R.C.P.(C.)
Cardiologist and Electrophysiologist, Toronto General Hospital/ UHN

Gary E. Newton, M.D., F.R.C.P.(C.)
Assistant Professor of Medicine, University of Toronto; Attending Cardiologist, Mount Sinai Hospital

Vivek Rao, M.D., Ph.D., F.R.C.S.(C.)
Assistant Professor of Surgery; Surgical Director, Cardiac Transplant and Mechanical Assist, Toronto General Hospital/UHN

Heather Ross, M.D., M.H.Sc., F.R.C.P.(C.)
Associate Professor, Divisions of Cardiology and Transplant, University of Toronto; Medical Director, Cardiac Transplant Program, Toronto General Hospital/UHN

Duncan Stewart, M.D., F.R.C.P.(C.), F.A.C.C.
Dexter Hung-Cho Man Chair and Director, Division of Cardiology, University of Toronto, St. Michael’s Hospital

Richard D. Weisel, M.D., F.R.C.S.(C.), F.A.C.C.
Professor and Chair, Division of Cardiac Surgery, University of Toronto; Staff Surgeon, Division of Cardiovascular Surgery, Toronto General Hospital/UHN

E. Douglas Wigle, M.D., F.R.C.P.(C.), F.A.C.C.
Professor, Department of Medicine, University of Toronto; Attending Cardiologist, Toronto General Hospital/UHN

Peter W. Zandstra, Ph.D.
L’Anson Associate Professor of Tissue Engineering, Canada Research Chair in Stem Cell Bioengineering, Institute for Biomaterials and Biomedical Engineering, University of Toronto

Guest Faculty:

Piero Anversa, M.D.
Professor and Vice Chairman, Department of Medicine, Director of Cardiovascular Research Institute, New York Medical College New York

J. Malcolm O. Arnold, M.D., F.R.C.P.(C.), F.A.C.P., F.A.C.C.
Professor of Medicine, Physiology and Toxicology, University of Western Ontario; Program Leader, Circulation Group, Lawson Health Research Institute London, Ontario, Canada

Jay N. Cohn, M.D., F.A.C.C.
Professor of Medicine; Director, Rasmussen Center for Prevention of Cardiovascular Disease, University of Minnesota Medical School Minneapolis

Michael S. Ewer, M.D., J.D.
Professor of Medicine, University of Texas; Cardiology Department, M.D. Anderson Cancer Center Houston

Thomas Force, M.D.
Investigator, Molecular Cardiology Research Institute, Tufts-New England Medical Center; Professor of Medicine, Tufts University School of Medicine Boston

Mihai Gheorghiade, M.D., F.A.C.C.
Associate Chief, Division of Cardiology; Chief, Cardiology Clinical Service; Clinical Practice Director and Professor of Medicine, Northwestern University Feinberg School of Medicine Chicago

Anil Gupta, M.D., F.R.C.P.(C.)
Staff Cardiologist, William Olser Health Centre Brampton, Ontario, Canada

Joshua M. Hare, M.D., F.A.C.C.
Professor of Medicine and Biomechanical Engineering; Director, Heart Failure and Cardiac Transplantation; Director, Cardiovascular Section, Institute for Cell Engineering, Johns Hopkins University School of Medicine Baltimore

Sharon Ann Hunt, M.D., F.A.C.C.
Professor, Cardiovascular Medicine, Stanford University Stanford, Calif.

Silviu M. Itescu, M.D.
Associate Professor, Departments of Surgery and Medicine; Director, Transplantation Immunology, Columbia University New York

Stuart D. Katz, M.D., F.A.C.C.
Associate Professor, Department of Medicine, Yale University, Yale New Haven Hospital New Haven, Conn.

Marvin A. Konstam, M.D., F.A.C.C.
Chief of Cardiology, Professor of Medicine, Tufts-New England Medical Center Boston

Eva Lonn, M.D., M.Sc., F.R.C.P.(C.), F.A.C.C.
Professor of Medicine, McMaster University; Staff Cardiologist, Hamilton Health Sciences-General Site Hamilton, Ontario, Canada

Alan S. Maisel, M.D., F.A.C.C.
Professor of Medicine, University of California San Diego; Director CCU and CHF Program, San Diego VA Health Care System San Diego

Douglas L. Mann, M.D., F.A.C.C.
Gordon Cain Chair and Professor of Medicine; Director, Winters Center for Heart Failure Research, Baylor College of Medicine Houston

Kenneth B. Margulies, M.D., F.A.C.C.
Associate Professor of Medicine & Physiology, Temple University School of Medicine Philadelphia

Dennis M. McNamara, M.D., F.A.C.C.
Associate Professor of Medicine; Director, Heart Failure/Transplantation Program, University of Pittsburgh Medical Center Pittsburgh

Christopher J. O’Donnell, M.D., F.A.C.C.
Associate Director, NHLBI’s Framingham Heart Study Medical Officer, National Heart, Lung, and Blood Institute; Attending Cardiologist, Massachusetts General Hospital; Assistant Professor, Harvard Medical School Boston

Ileana L. Pina, M.D., F.A.C.C.
Professor of Medicine Case, Western Reserve University; Director of Heart Failure and Cardiac Transplantation, Division of Cardiology, University Hospitals of Cleveland Cleveland

Richard J. Rodeheffer, M.D., F.A.C.C.
Professor or Medicine, Mayo Medical School Rochester, Minn.

Hani N. Sabbah, Ph.D., F.A.C.C.
Professor of Medicine; Director, Cardiovascular Research, Henry Ford Health Services Detroit

Francis G. Spinale, M.D., Ph.D., F.A.C.C.
Professor and Vice Chair Department of Surgery, Medical University of South Carolina Charleston, S.C.

Anthony S.L. Tang, M.D., F.R.C.P.(C.), F.A.C.C.
Professor of Medicine, Director of Electrophysiology, Director of Cardiology Research, University of Ottawa Heart Institute Ottawa, Ontario, Canada

Robin J. Trupp, M.S.N., A.C.N.P., C.C.R.N., C.C.R.C.
Heart Failure Program Director, Ohio State University Columbus, Ohio

Michel White, M.D., F.R.C.P.(C.), F.A.C.C.
Director, Heart Failure Research Program, Montreal Heart Institute, University of Montreal Montreal

Michael R. Zile, M.D., F.A.C.C.
Charles Ezra Daniel Professor of Medicine, Medical University of South Carolina Charleston, S.C.

The Eighth Annual
Toronto International Heart Failure Summit: From Pathophysiology to Clinical Practice —2005

Directed by Peter P. Liu, M.D., F.R.C.P. (C.), F.A.C.C., and John D. Parker, M.D., F.R.C.P.(C.), F.A.C.C.

Offered in cooperation with the Heart & Stroke/Richard Lewar Centre for Cardiovascular Research at the University of Toronto, focusing on novel advances in pathophysiology and therapeutics in the post-genome era.

June 5-7, 2005
Toronto, Ontario, Canada

Schedule of Events

SUNDAY | MONDAY | TUESDAY

Sunday, June 5

7:00 a.m. Registration and Breakfast

7:50 a.m. Introduction and Welcome—Drs. Liu and Parker

Heart Failure: A Year of Progress—Dr. Liu, presiding

8:00 a.m. Heart Failure a Year in Review — Clinical Trials—Dr. Arnold

8:25 a.m. Heart Failure a Year in Review — Basic—Dr. Force

8:50 a.m. Heart Failure in the Community: Clinical Triumphs and Challenges—Dr. O’Donnell

9:15 a.m. Discussion

9:25 a.m. Debate: For the Heart Failure Patient, Combination of ACEi + ARB Is Better than ACEi + Aldo Antagonist

Pro — Dr. Arnold
Con — Dr. Konstam

10:05 a.m. Nutrition Break

Diastolic Heart Failure—Dr. Wigle, presiding

10:40 a.m. Pathophysiologic Mechanisms of Diastolic Heart Failure —Dr. Zile

11:00 a.m. Epidemiology: The Rising Tide of Diastolic Heart Failure — Are We Prepared?—Dr. Rodeheffer

11:20 a.m. Does Ejection Fraction (to Diagnose “Diastolic Dysfunction”) Help in Selecting Therapy for Heart Failure Patients?—Dr. Konstam

11:40 a.m. Clinical Therapy Today and Tomorrow—Dr. Zile

12:00 p.m. Discussion

12:20 p.m. Lunch Provided

Remodeling and Heart Failure—Dr. Backx, presiding

1:20 p.m. Molecular Aspects of Remodeling and Reverse Remodeling—Dr. Margulies

1:40 p.m. Alterations of the Matrix as Part of the Remodeling Process—Dr. Spinale

2:00 p.m. Identifying Novel Strategies for Treating Heart Failure—Dr. Force

2:20 p.m. Remodeling as a Therapeutic Target — Time Has Come?—Dr. Cohn

2:40 p.m. Passive Cardiac Restraint Devices: Time to Put the Heart in a Bind?—Dr. Mann

3:00 p.m. Discussion

3:10 p.m. Nutrition Break

Neurohumoral Modulators in Heart Failure—Dr. Moe, presiding

3:30 p.m. Interaction of Cytokines and Adrenergic Signaling Systems in Heart Failure—Dr. Mann

3:50 p.m. Beta and Alpha Adrenergic Polymorphism in Predicting Heart Failure Response—Dr. McNamara

4:10 p.m. Discussion

Workshops and Case Discussions

4:15 p.m. Workshop I (Participants choose one)

Workshop Options:

A. Challenging Clinical Cases of Heart Failure Management—Drs. Arnold, Cohn, Margulies and Wigle

B. Diastolic Heart Failure: Trials and Tribulations—Drs. Mann, Spinale and Zile

C. How to Rescue Patients Out of Acute Heart Failure?—Drs. Hunt, Newton and Ross

D. Heart Failure Jeopardy: Compare Your Knowledge to the State of Art—Drs. Force, Gupta and Liu

5:30 p.m. Adjournment

Monday, June 6

7:00 a.m. Registration and Breakfast

The Cardio Renal Connection and BNP in Heart Failure—Dr. Moe, presiding

8:00 a.m. Cardio Renal Connection: Pathophysiology and Implications for Prognosis and Management—Dr. White

8:20 a.m. The Role of BNP/NT-proBNP in Heart Failure Detection—Dr. Maisel

8:40 a.m. The Role of Neseritide in Heart Failure Therapy: When and for Whom?—TBA

9:00 a.m. Age-Related Changes in the Heart Leading to Heart Failure—Dr. Spinale

9:20 a.m. BNP and Other Biomarkers as a Guide for Heart Failure Therapy—Dr. Maisel

9:40 a.m. Discussion

10:00 a.m. Nutrition Break

Cardiac Regenerative Medicine—Dr. Li, presiding

10:30 a.m. Embryonic Stem Cells for Cardiac Applications—Dr. Zandstra

10:55 a.m. Resident Cardiac Stem Cells—Dr. Anversa

11:20 a.m. Regenerative Therapies for Cardiovascular Diseases: Buy or Cell?—Dr. Stewart

11:45 a.m. Mechanisms of Cell-Based Therapy in Terms of Benefit—Dr. Itescu

12:10 p.m. Can We Create a New Heart Using Artificial Matrix and Cells?—Dr. Weisel

12:35 p.m. Discussion

12:45 p.m. Lunch Provided

Arrhythmias and Devices in Heart Failure—Dr. Nanthakumar, presiding

1:45 p.m. Atrial Fibrillation: Management Setting of Heart Failure—Dr. Dorian

2:10 p.m. Beyond Support: Can Devices Improve Cardiovascular Structure and Function?—Dr. Konstam

2:35 p.m. Debate: Cardiac Resynchronization Should Be Decided Based on Appropriate Clinical Criteria?

Pro — Dr. Parker
Con — Dr. Tang

3:15 p.m. Nutrition Break

Workshops and Case Discussions

3:45 p.m. Workshop I (Participants choose one)

Workshop Options:

A. How to Use BNP or NT-proBNP for Management of Heart Failure?—Drs. Liu and Maisel

B. When to Consider Devices/Artificial Hearts for the Heart Failure Patient and What to Expect?—Drs. Hunt, Parker and Sabbah

C. How to Rescue Patients Out of Acute Heart Failure?—Drs. Arnold, Delgado and White

D. Challenging Clinical Cases of Heart Failure Management—Dr. Moe, Pina and Ross


5:00 p.m. Adjournment

5:30 p.m. Departure for Evening Special Event Venue (Complimentary for Registrants)


Tuesday, June 7

7:00 a.m. Registration and Breakfast

Nitroso Redox Regulation in Heart Failure—Dr. Newton, presiding

8:00 a.m. Oxidative Stress and Cardiac Function—Dr. Mak

8:20 a.m. Nitric Oxide and Free Radicals in Heart Failure—Dr. Hare

8:40 a.m. A-HeFT: Clinical Implications and Applications—Dr. Cohn

9:00 a.m. Chemotherapy-Induced Heart Failure—Dr. Ewer

9:20 a.m. Discussion

9:30 a.m. Nutrition Break


Issues and Clinical Care of the Heart Failure Patient—Dr. Delgado, presiding

10:00 a.m. Quality Care and Quality Indicators for Heart Failure—Dr. Pina

10:20 a.m. Gaps in Heart Failure Care: How Do We Address Them?—Dr. Arnold

10:40 a.m. Vasopressin Antagonist in Heart Failure and Hyponatremia—Dr. Gheorghiade

11:00 a.m. Exercise and the Heart Failure Patient: Why and How?—Dr. Pina

11:20 a.m. Is There Still HOPE After PEACE? How Do We Interpret the Suite of ACEi Trials in Coronary Disease?—Dr. Lonn

11:40 a.m. Discussion

12:00 p.m. Lunch Provided

Practical and Novel Considerations in Heart Failure—Dr. Parker, presiding

1:00 p.m. Anemia as a Marker and Treatment Target in Heart Failure—Dr. Katz

1:20 p.m. At the End of the Road: Issues in Palliative Care—Ms. Trupp

1:40 p.m. Right Heart Failure: Approaches to Diagnosis and Therapy—Dr. Newton

2:00 p.m. Electrical Neurostimulation for the Treatment of Heart Failure—Dr. Sabbah

2:20 p.m. Discussion

2:30 p.m. Nutrition Break

Treatment and Surgical Options of Severe or Decompensated Heart Failure—Dr. Ross, presiding

3:00 p.m. The PA Line May Not Kill, But When Would One Consider Tailored Therapy?—Dr. Hunt

3:20 p.m. How to Approach the Treatment of the Acute Decompensated Heart Failure Patient?—Dr. Gheorghiade

3:40 p.m. Device or Transplant — Who is the Real Patient Suitable for Transplant?—Dr. Hunt

4:00 p.m. Cardiac Transplantation — Long-Term Results—Dr. Ross

4:20 p.m. LV Reconstruction for Ischemic Cardiomyopathy—Dr. Rao

4:40 p.m. Discussion

5:00 p.m. Summary and Concluding Remarks—Dr. Liu

5:15 p.m. Adjournment

Program Evaluation and CME credit statements will be collected at this time.

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