PRAGUE 14: Antithrombotic Therapy Before Surgery Associated With Higher Bleeding Complications
The prospective study looked at 1,211 patients undergoing acute and elective major non-cardiac surgery over 2.5 years with at least one known cardiac disease. Results showed that cardiovascular complications occurred in 91 patients, and bleeding occurred in 159 patients. Further, in-hospital mortality was 3.9 percent.
The investigators conclude that antithrombotic therapy interruption shortly before surgery was not associated with lower risk of perioperative cardiovascular complications in the overall population, but among elective surgical patients, "there was a trend towards increased risk of complications when [aspirin] was stopped four to eight days prior to surgery." Moving forward, "a more detailed analysis on the subgroup of elective surgical patients is planned," they add.
Clinical Topics: Cardiac Surgery, Invasive Cardiovascular Angiography and Intervention
Keywords: Heart Diseases, Risk, Multivariate Analysis, Hospital Mortality, Thrombosis, Cardiac Surgical Procedures, Hemorrhage
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