Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine - SEARCH


Although a few studies have demonstrated a beneficial effect on cardiovascular outcomes with high-dose statins versus low-dose statins in patients with acute coronary syndromes, there was also a higher incidence of adverse effects, including hepatic and musculoskeletal. Similarly, although observational studies seem to suggest a beneficial effect of homocysteine lowering with folic acid in patients with coronary artery disease, this has not borne out in prospective studies.