Safety and Efficacy of a Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 Serine Protease, SAR236553/REGN727, in Patients With Primary Hypercholesterolemia Receiving Ongoing Stable Atorvastatin Therapy - PCSK9 Inhibition in Patients With Primary Hypercholesterolemia on Atorvastatin

Description:

Serum proprotein convertase subtilisin kexin 9 (PCSK9) binds to low-density lipoprotein (LDL) receptors, increasing serum LDL cholesterol (LDL-C). The current trial is a phase II trial designed to study the safety and efficacy of SAR236553, a monoclonal antibody to PCSK9, in patients with primary hypercholesterolemia.