Xanthine Oxidase Inhibition for Hyperuricemic Heart Failure Patients | Clinical Trial - EXACT-HF


The goal of the trial was to evaluate treatment with the xanthine oxidase inhibitor allopurinol compared with placebo among patients with symptomatic heart failure and elevated serum uric acid levels.

Contribution to the Literature: The EXACT-HF trial failed to show that allopurinol in symptomatic heart failure improved clinical status, exercise capacity, or quality of life.