Effects of AMG 145 on Low-Density Lipoprotein Cholesterol Levels: Results From 2 Randomized, Double-Blind, Placebo-Controlled, Ascending-Dose Phase 1 Studies in Healthy Volunteers and Hypercholesterolemic Subjects on Statins

Study Questions:

What are the safety, tolerability, and effects of AMG 145 (a proprotein convertase subtilisin/kexin type 9 [PCSK-9] enzyme inhibitor) on low-density lipoprotein cholesterol (LDL-C) in healthy and hypercholesterolemic subjects on statin therapy?