Effect of the PCSK9 Monoclonal Antibody, AMG 145, in Homozygous Familial Hypercholesterolemia

Study Questions:

Human monoclonal antibodies to proprotein convertase subtilisin/kexin 9 (PCSK-9) reduce low-density lipoprotein cholesterol (LDL-C) in heterozygous familial hypercholesterolemia. What is the efficacy and safety of AMG 145, a PCSK-9 inhibitor, in patients with homozygous hypercholesterolemia (HoFH)?