Perspective:

The left atrial appendage (LAA) is a predominant source of thrombus formation, leading to significant thromboembolic events in patients with nonvalvular atrial fibrillation (AF). Recent mechanical approaches designed to exclude the LAA from the circulation have recently opened up new therapeutic approaches to preventing stroke in AF. In order to ensure success of the LAA occlusion procedure, operators/institutions must commit to a strong collaborative approach to optimize outcomes and resource utilization. Incoming referrals to the center must be carefully screened and evaluated prior to their appointment; a screening checklist may be utilized to ensure that the appropriate candidates are being selected for appointments, with comprehensive evaluation by a multidisciplinary team prior to the procedure.