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EAGLE ET AL., PERIOPERATIVE CARDIOVASCULAR EVALUATION FOR NONCARDIAC SURGERY UPDATE
http://www.acc.org/clinical/guidelines/perio/update/periupdate_index.htm

ACC/AHA Guideline Update for Perioperative Cardiovascular Evaluation for Noncardiac Surgery

A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1996 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery)

 

Revised Table 7. Myocardial Perfusion Dipyridamole-Thallium Imaging for Preoperative Assessment of Cardiac Risk


Perioperative Events

Author

n*

Patients With Ischemia by TI-Rd (%)

Events: MI/Death

(%)

Ischemia Positive RD Scan

Positive Predictive

Value

Normal Scan

Negative

Predictive

Value

Comments

Vascular surgery

Boucher 1985 (119)

48

16 (33)

3 (6)

19% (3/16)

100% (32/32)

First study to define risk of thallium redistribution

Cutler 1987 (120)

116

54 (47)

11 (10)

20% (11/54)

100% (60/60)

Only aortic surgery

Fletcher 1988 (121)

67

15 (22)

3 (4)

20% (3/15)

100% (56/56)

Sachs 1988 (122)

46

14 (31)

2 (4)

14%(2/14)

100% (24/24)

Eagle 1989 (21)

200

82 (41)

15 (8)

16% (13/82)

98% (61/62)

Defined clinical risk

McEnroe 1990 (123)

95

34 (36)

7 (7)

9% (3/34)

96% (44/46)

Fixed defects predict events

Younis 1990 (124)

111

40 (36)

8 (7)

15% (6/40)

100% (51/51)

Includes long-term follow-up

Mangano 1991 (125)

60

22 (37)

3 (5)

5% (1/22)

95% (19/20)

Managing physicians blinded to scan result

Strawn 1991 (126)

68

N/A

4 (6)

N/A

100% (21/21)

Watters 1991 (127)

26

15 (58)

3 (12)

20% (3/15)

100% (11/11)

Includes echocardiograhic (TEE) studies

Hendel 1992 (128)

327

167 (51)

28 (9)

14% (23/167)

99% (97/98)

Included long-term follow-up

Lette 1992 (129)

355

161 (45)

30 (8)

17% (28/161)

99% (160/162)

Used quantitative scan index

Madsen 1992 (130)

65

45 (69)

5 (8)

11% (5/45)

100% (20/20)

Brown 1993 (131)

231

77 (33)

12 (5)

13% (10/77)

99% (120/121)

Prognostic utility enhanced by combined scan and clinical factors

Kresowik 1993 (132)

170

67 (39)

5 (3)

4% (3/67)

98% (64/65)

Baron 1994 (133)

457

160 (35)

22 (5)

4% (7/160)

96% (195/203) NFMI only

Did not analyze for cardiac deaths; no independent value of scan

Bry 1994 (134)

237

110 (46)

17 (7)

11% (12/110)

100% (97/97)

Cost-effectiveness data included

Koutelou 1995 (378)

106

47 (44)

3 (3)

6% (3/47)

100% (49/49)

Used adenosine/SPECT thallium imaging

Marshall 1995 (387)

117

55 (47)

12 (10)

16% (9/55)

97% (33/34)

Used adenosine thallium and sestamibi. Size of ischemic defect enhanced prognostic utility

Van Damme 1997 (388)

142

48 (34)

3 (2)

N/A

N/A

Used dobutamine SPECT sestamibi and echocardiographic imaging. Echocardiographic and nuclear scan prognostic utility were equivalent

Nonvascular surgery†xxxxxx

Camp 1990 (135)

40

9 (23)

6 (15)

67% (6/9)

100% (23/23)

Diabetes mellitus, renal transplant

Iqbal 1991 (136)

31

11 (41)

3 (11)

27% (3/11)

100% (20/20)

Exercise 86%, diabetes mellitus, pancreas transplant

Coley 1992 (137)

100

36 (36)

4 (4)

8% (3/36)

98% (63/64)

Define clinical risk factors in patients with known or suspected CAD

Shaw 1992 (138)

60

28 (47)

6 (10)

21% (6/28)

100% (19/19)

Used adenosine

Takase 1993 (139)

53

15 (28)

6 (11)

27% (4/15)

100% (32/32)

Patients with documented or suspected CAD include rest echocardiogram

Younis 1994 (140)

161

50 (31)

15 (9)

18% (9/50)

98% (87/89)

Intermediate- to high-risk CAD

Stratman 1996 (270)

229

67 (29)

10 (4)

6% (4/67)

99% (91/92)

Used dipyridamole sestamibi and noted fixed defect had more prognostic utility than transient defect

Rd indicates redistribution; CAD indicates coronary artery disease; MI, myocardial infarction; n*, number of patients who underwent surgery; N/A, not available; NFMI, nonfatal myocardial infarction; SPECT, single photon emission computed tomography; TEE, transesophageal echocardiography.

†Studies utilizing pharmacological and/or exercise thallium testing.

 

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