http://www.acc.org/Feed?clinicalTopicID=45d25f86-5c8b-42a6-818b-c3998baad19a Clinical Topic Feed: Lipid Metabolism en /Latest-in-Cardiology/Articles/2026/03/25/21/27/mon-1045am-coralreef-acc-2026 The novel PCSK9 oral inhibitor enlicitide effectively lowered LDL-C in adults already being treated with statins, demonstrating a potential role as an add-on option for patients not meeting LDL-C goals, according to results from the CORALreef AddOn trial presented during an Investigative Horizons session at ACC.26 in New Orleans and simultaneously published in JACC. 1774885560000 Articles and Stories /Latest-in-Cardiology/Articles/2026/03/25/21/27/mon-830am-essence-acc-2026 In patients with moderate hypertriglyceridemia, significant reductions in triglyceride and remnant cholesterol levels with olezarsen, on top of standard-of-care lipid-lowering therapy, did not translate into a significant change from baseline in noncalcified coronary plaque volume (NCPV), according to results from Essence-CTA, a substudy of the Essence-TIMI 73b trial, presented during a Late-Breaking Clinical Trial session at ACC.26 in New Orleans and simultaneously published in Circulation. 1774877580000 Articles and Stories /Latest-in-Cardiology/Articles/2026/03/25/21/27/sat-345pm-vesaliuscv-acc-2026 The PCSK9 inhibitor evolocumab reduced the risk of a first major cardiovascular event in patients with diabetes without known significant atherosclerosis, according to a prespecified subgroup analysis of the VESALIUS-CV trial, presented during a Late-Breaking Clinical Trial session at ACC.26 in New Orleans and simultaneously published in JAMA. 1774730760000 Articles and Stories /Latest-in-Cardiology/Journal-Scans/2026/03/24/18/20/ACC-Scientific-Statement-Highlights-Emerging-Role-of-Gene-Editing A new ACC Scientific Statement outlines the rapidly evolving landscape of gene-editing therapies and their growing relevance to cardiovascular disease, offering clinicians an overview of both the promise and the challenges of this transformative technology. 1774536660000 Articles and Stories /Latest-in-Cardiology/Articles/2026/03/18/00/50/eagles-eye-view-18mar2025 In this week’s View, Dr. Eagle looks at data from the STS/ACC TVT Registry on off label transcatheter valve interventions that demonstrate reduced residual tricuspid regurgitation (TR) and improved quality of life. 1773842400000 Articles and Stories /Latest-in-Cardiology/Journal-Scans/2026/03/13/15/20/ACC-AHA-Release-New-Clinical-Guideline-For-Managing-Dyslipidemia The new ACC/AHA Guideline on the Management of Dyslipidemia offers a comprehensive “one-stop shop” for addressing the evaluation, management and monitoring of individuals with dyslipidemias, including high blood cholesterol, hypertriglyceridemia, and elevated lipoprotein(a) (Lp[a]). 1773415860000 Articles and Stories /Latest-in-Cardiology/Articles/2026/03/01/01/Cover-Story-The-Adipokine-Hypothesis Fourteen hours a day, nearly every day for a year. That's how long it took Milton Packer, MD, FACC, to write his groundbreaking hypothesis connecting adipokines and visceral adiposity to heart failure with preserved ejection fraction (HFpEF). 1772371140000 Articles and Stories /Latest-in-Cardiology/Articles/2026/03/01/01/From-the-Member-Sections-Dietary-Guidelines The Dietary Guidelines for Americans (DGA), released every five years by the U.S. Department of Health and Human Services and U.S. Department of Agriculture, are a major driver of U.S. food policy, diet quality and cardiovascular health. 1772370960000 Articles and Stories /Latest-in-Cardiology/Articles/2026/03/01/01/JACC-in-a-Flash Featured topics and Editors' Picks from all of ACC's JACC Journals. 1772370600000 Articles and Stories /Latest-in-Cardiology/Journal-Scans/2026/02/17/14/32/Unpacking-CV-Nutritional-Controversies-in-2026 In response to increased controversy over what makes up a healthy diet, a recent JACC: Advances State-of-the-Art Review dives into the evidence both for and against several controversial foods and provides recommendations based on the available literature on cardiovascular health and outcomes. 1771434420000 Articles and Stories