http://www.acc.org/Feed?clinicalTopicID=677b3288-77e4-47f8-8697-3e2ce6a4dd87 Clinical Topic Feed: Anticoagulation Management en /Latest-in-Cardiology/Journal-Scans/2026/04/22/11/23/OCEANIC-STROKE Asundexian lowered the risk of ischemic stroke and major cardiovascular events, without increasing the risk of major bleeding, in patients with noncardioembolic stroke or high-risk transient ischemic attack (TIA) taking antiplatelet therapy, according to results from the phase 3, double-blind OCEANIC-STROKE trial, published April 15 in NEJM. 1776865440000 Articles and Stories /Latest-in-Cardiology/Journal-Scans/2026/04/21/16/07/Current-Evidence-and-Strategies The influences of sex hormone therapy – for contraception, treatment of heavy menstrual bleeding, hormone-replacement therapy, gender-affirming care therapy, etc. – on venous thrombotic and cardiovascular risk was explored in a Review Article published April 15 in NEJM. 1776793020000 Articles and Stories /Latest-in-Cardiology/Articles/2026/04/01/15/58/cardiacast_01apr2026 In this episode, Gregory Piazza, MD, FACC, Elvira Grandone, MD, PhD, and Abbey R. Kruper, PsyD, ABPP walk through the clinical and emotional challenges of the link between thrombosis and fertility. 1775232180000 Articles and Stories /Latest-in-Cardiology/Articles/2022/01/01/01/01/ACC-Featured-Jobs Ready to explore a new professional opportunity? Browse the list below of featured jobs and take the next step in your career! 1775037480000 Articles and Stories /Latest-in-Cardiology/Articles/2026/03/25/21/27/sat-930am-championaf-acc-2026 Device-based left atrial appendage (LAA) closure was comparable to non-vitamin K antagonist oral anticoagulant (NOAC) therapy in reducing the combined rate of death from cardiovascular causes, stroke, or systemic embolism at three years in patients with atrial fibrillation (AFib) who were candidates for anticoagulation, based on findings from the CHAMPION-AF trial presented at ACC.26 and simultaneously published in NEJM. In addition, LAA closure was superior to long-term NOAC therapy for pre-specified non–procedure-related bleeding over the same time period. 1774708380000 Articles and Stories /Latest-in-Cardiology/Articles/2026/03/25/21/27/sat-930am-hipeitho-acc-2026 In patients with acute, intermediate-risk pulmonary embolism (PE), ultrasound-facilitated, catheter-directed fibrinolysis plus anticoagulation led to a lower risk of PE-related death, cardiopulmonary decompensation or collapse, or recurrence of PE compared with anticoagulation alone. These findings from the HI-PEITHO trial were presented at ACC.26 in New Orleans and simultaneously published in NEJM. 1774708320000 Articles and Stories /Latest-in-Cardiology/Articles/2026/03/25/21/27/sat-930am-stemidtu-acc-2026 Compared with immediate PCI alone, the combination of mechanical left ventricular (LV) unloading using a transvalvular micro-axial flow pump (TV-mAFP) plus delayed PCI did not reduce infarct size in patients with anterior STEMI without cardiogenic shock, according to findings from the STEMI-DTU trial presented at ACC.26 and simultaneously published in JACC. 1774708320000 Articles and Stories /Latest-in-Cardiology/Articles/2026/03/04/14/11/eagles-eye-view-04mar2025 In this week’s View, Dr. Eagle looks at increased one-year mortality in younger patients undergoing transcatheter aortic valve replacement (TAVR). 1772636400000 Articles and Stories /Latest-in-Cardiology/Articles/2026/03/02/17/40/Key-Insights-From-the-ANDES-Trial The ANDES (Antithrombotic Therapy After Left Atrial Appendage Closure: Direct Oral Anticoagulants vs Dual Antiplatelet Therapy) trial results demonstrated that, in patients with nonvalvular atrial fibrillation who underwent left atrial appendage closure (LAAC), short-term direct oral anticoagulant (DOAC) therapy... 1772478060000 Articles and Stories /Latest-in-Cardiology/Articles/2026/03/01/01/Focus-on-EP In patients with atrial fibrillation (AFib), the most feared consequence is not the arrhythmia itself but the associated risk of stroke. Although decision-making tools to assess stroke risk in nonvalvular AFib have become more nuanced, the threshold to recommend oral anticoagulation (OAC) for stroke prevention has become lower over time. 1772370840000 Articles and Stories