Research looking at ketone body utilization found that β-hydroxybutyrate (βOHB) extraction rate in the coronary circulation was suppressed by the ischemic condition. The research will be presented at AHA 2018 in Chicago, IL, and published Nov. 5 in the Journal of the American College of Cardiology.

Yuichiro Arima, MD, PhD, et al., retrospectively looked at 171 patients with angina-like chest pain undergoing an acetylcholine provocation test. The lactate and βOHB concentrations at the aortic root and coronary sinus were measured. Patients were categorized into two groups depending on coronary lactate production to consider the effect of acute myocardial ischemia on β-hydroxybutyrate (βOHB) extraction.

Results showed that there was "no significant difference" in coronary βOHB extraction between the two groups. However, coronary βOHB extraction after the acetylcholine provocation test was significantly suppressed in the provoked group.

The authors conclude that their findings "could help clarify the pathophysiology of cardiac energy metabolism under the anaerobic condition induced by myocardial ischemia."

Clinical Topics: Dyslipidemia, Atherosclerotic Disease (CAD/PAD), Lipid Metabolism

Keywords: AHA18, AHA Annual Scientific Sessions, Acetylcholine, Lactic Acid, Coronary Sinus, Myocardial Ischemia, Coronary Artery Disease, Coronary Circulation, Hydroxybutyrates, Energy Metabolism, Chest Pain, Ketones, Retrospective Studies

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