Journal Wrap | Lifestyle Intervention Effective in Prediabetes; Aficamten Tops Metoprolol For Exercise in oHCM; More
The hottest research from various peer-reviewed journals – handpicked weekly by the ACC.
Lifestyle Intervention Lowers Multimorbidity Risk in Prediabetes
An intensive lifestyle intervention may offer lasting protection against multimorbidity in adults with prediabetes, according to a 21-year Diabetes Prevention Program follow-up analysis published in JAMA. Metformin was not significantly different from placebo.
TAVR, Surgery Show Similar Valve Durability at 7 Years
Seven-year data from PARTNER 3 show TAVR offers valve durability comparable with surgery in low-risk patients with symptomatic severe aortic stenosis, with similarly low rates of structural valve deterioration, bioprosthetic valve failure (BVF) and reintervention, based on an ad hoc analysis published in JAMA Cardiology.
Pilot Study Tests GDMT Withdrawal Post AFib Ablation
Stopping guideline-directed medical therapy (GDMT) after catheter ablation may be feasible for some patients with atrial fibrillation (AFib)-mediated cardiomyopathy, but the small pilot study suggests careful follow-up is needed, with heart failure (HF) deterioration occurring in 12% of patients after withdrawal, according to findings from DEFINITION-AF published in JAMA Network Open.
Aficamten Tops Metoprolol For oHCM Exercise Intolerance
Aficamten monotherapy was superior to metoprolol in promoting adaptation to multiple phases of exercise in patients with symptomatic obstructive HCM (oHCM), according to a prespecified analysis of the MAPLE-HCM trial published in JAMA Cardiology.
Clinical Topics: Arrhythmias and Clinical EP, Cardiac Surgery, Cardiovascular Care Team, Diabetes and Cardiometabolic Disease, Heart Failure and Cardiomyopathies, Invasive Cardiovascular Angiography and Intervention, Prevention, Valvular Heart Disease, SCD/Ventricular Arrhythmias, Atrial Fibrillation/Supraventricular Arrhythmias, Aortic Surgery, Cardiac Surgery and Arrhythmias, Cardiac Surgery and Heart Failure, Cardiac Surgery and VHD, Acute Heart Failure, Interventions and Structural Heart Disease, Diet, Exercise
Keywords: Cardiology Magazine, ACC Publications, CM-Sep-2026, Prediabetic State, Aortic Valve Stenosis, Diet, Healthy, Primary Prevention, Metformin, Exercise, Transcatheter Aortic Valve Replacement, Heart Valve Diseases, Cardiac Surgical Procedures, Catheter Ablation, Atrial Fibrillation, Exercise Tolerance, Cardiomyopathy, Hypertrophic, Metoprolol, Heart Failure, Cardiomyopathies
