Log in to MyACC
Long-Term Prognosis of Takotsubo Syndrome
Study Questions:
What are the short- and long-term outcomes in Takotsubo syndrome (TTS) based on different triggers?
Methods:
The investigators enrolled patients with TTS from the International Takotsubo Registry. Long-term mortality of patients with TTS was compared to an age- and sex-matched cohort of patients with acute coronary syndrome (ACS). In addition, short- and long-term outcomes were compared between different groups according to triggering conditions.
Results:
Overall, TTS patients had a comparable long-term mortality risk with ACS patients. Of 1,613 TTS patients, an emotional trigger was detected in 485 patients (30%). Of 630 patients (39%) related to physical triggers, 98 patients (6%) had acute neurologic disorders, while in the other 532 patients (33%), physical activities, medical conditions, or procedures were the triggering conditions. The remaining 498 patients (31%) had no identifiable trigger. TTS related to physical stress showed higher mortality rates than ACS patients during long-term follow-up, whereas those with TTS related to emotional stress had better outcomes compared with ACS patients.
Conclusions:
The authors concluded that overall, TTS patients had long-term outcomes comparable to age- and sex-matched ACS patients.
Perspective:
This study reports that overall, TTS patients had a similar long-term outcome compared with age- and sex-matched ACS patient outcomes. Furthermore, TTS can either be benign or a life-threatening condition depending on the inciting stress factor. TTS patients with events related to emotional stress appear to have a favorable short- and long-term prognosis, but TTS secondary to neurologic diseases have the worst short-term prognosis. In fact, TTS secondary to neurologic diseases and TTS secondary to physical activities, medical conditions, or procedures had significantly higher mortality rates compared with ACS during long-term follow-up. Perhaps an individualized approach to TTS based on trigger may improve prognosis.
Clinical Topics: Acute Coronary Syndromes, Cardiovascular Care Team, Diabetes and Cardiometabolic Disease, Heart Failure and Cardiomyopathies, Prevention, Acute Heart Failure, Exercise, Stress
Keywords: Acute Coronary Syndrome, Exercise, Heart Failure, Nervous System Diseases, Precipitating Factors, Prognosis, Secondary Prevention, Stress, Psychological, Takotsubo Cardiomyopathy
< Back to Listings
