Patients with severe aortic stenosis at low surgical risk treated with a transcatheter aortic valve replacement (TAVR) had meaningful early as well as late health status benefits compared with similar patients treated with a surgical aortic valve replacement (SAVR). The findings from the PARTNER 3 quality of life substudy were presented Sept. 29 at TCT 2019 and simultaneously published in the Journal of the American College of Cardiology.

Suzanne J. Baron, MD, MSc, et al., reviewed data from the PARTNER 3 trial for patients who were enrolled between March 2016 and October 2017. Of the 1,000 patients enrolled, 950 were assigned to either the TAVR or SAVR cohorts of the trial. Patients in the TAVR cohort had moderate to large improvements in all health status measures at one month compared with their baseline health status. Similar benefits were seen at six months and one year.

Conversely, at one month, patients in the SAVR cohort had lower scores on scales assessing physical function. At six months, the SAVR patients showed substantial improvement on all health status scales compared with their baselines, and the improvement was sustained at one year.

For the primary outcome of change in the Kansas City Cardiomyopathy Questionnaire-Overall Summary, at one month there was a 16.0 point difference favoring TAVR over SAVR (p<0.001). More patients in the TAVR vs. SAVR group had an excellent outcome (alive with KCCQ-OS ≥75 and no significant decline from baseline) at six months (90.3 percent vs. 85.3 percent; p=0.03) and 12 months (87.3 percent vs. 82.8 percent; p=0.07).

"In addition to TAVR being associated with an early benefit over SAVR on all health status measures, TAVR was also associated with persistent benefits in disease-specific health status at one year compared with SAVR," wrote the researchers.

Longer term follow-up is needed to determine whether these findings are durable beyond one year in the low risk patient population, researchers said.

Keywords: TCT19, Transcatheter Cardiovascular Therapeutics, Angiography, Aortic Valve, Aortic Valve Stenosis, Transcatheter Aortic Valve Replacement, Heart Valve Prosthesis, Percutaneous Coronary Intervention

< Back to Listings