In this episode, hosts Rosy Thachil, MD, FACC, and Shashank Sinha, MD, FACC, are joined by Jacob Jentzer, MD, FACC, and Ami Bhatt, MD, FACC, Chief Innovation Officer of the American College of Cardiology, for an engaging discussion on AI in the CICU: Transforming Cardiac Critical Care. The conversation explores how artificial intelligence (AI) is beginning to reshape cardiac critical care—from improving clinical decision support and hemodynamic monitoring to predict patient deterioration and optimizing CICU workflows. The panel also discusses the opportunities and challenges of integrating AI into everyday practice and what the future may hold for clinicians caring for the sickest cardiovascular patients.