A new JACC focus Issue on amyloid heart disease reflects “the rapid evolution of how we detect, stage and treat transthyretin amyloid cardiomyopathy,” writes JACC Editor-In-Chief Harlan M. Krumholz, MD, SM, FACC. Read new analyses from ATTRibute-CM, the 2025 ACC Concise Clinical Guidance on Transthyretin Cardiac Amyloidosis, studies examining treatment strategies and more. See the full issue.