The latest issue of JACC: CardioOncology is a focus issue that explores the growing intersection of immunology and cardio-oncology, highlighting how immune pathways influence both cancer and cardiovascular health. Featuring expert reviews, primers, and pioneering research, the collection examines the cardiovascular effects of cancer therapies, emerging biomarkers and the shared biology driving outcomes across both fields. Explore the issue and uncover the latest science shaping the future of immunology and cardio-oncology.