Log in to MyACC
Functional Testing Underlying Revascularization - FUTURE
Contribution To Literature:
The FUTURE trial was terminated early, but showed similar event rates for FFR-guided versus angiography-guided revascularization.
Description:
The goal of the trial was to evaluate fractional flow reserve (FFR)-guided revascularization compared with angiography-guided revascularization among patients with ≥2 coronary stenoses (≥50%).
Study Design
- Randomized
- Parallel
Patients with multivessel coronary artery disease were randomized to FFR-guided revascularization versus angiography-guided revascularization.
Inclusion criteria:
- Stable patients with at least 2 coronary stenoses (≥50%).
- Total number of enrollees: 864
- Duration of follow-up: 1 year
- Percentage with diabetes: 32%
Other salient features/characteristics:
- SYNTAX score: mean 18.5
Principal Findings:
The primary outcome, all-cause death, myocardial infarction, or stroke, occurred in 14.4% of the FFR group compared with 14.6% of the angiography group (p = 0.94).
Adverse events were higher in the FFR group when SYNTAX score was ≥32.
Interpretation:
Among patients with multivessel coronary disease, FFR-guided revascularization resulted in similar outcomes compared with angiography-guided revascularization. Unfortunately, this trial was terminated early due to an unexplained increase in mortality in the FFR group.
References:
Presented by Dr. Gilles Rioufo at the European Society of Cardiology Congress, Munich, Germany, August 25, 2018.
Keywords: ESC Congress, ESC18, Angina Pectoris, Coronary Artery Disease, Coronary Stenosis, Fractional Flow Reserve, Myocardial, Myocardial Infarction, Myocardial Ischemia, Myocardial Revascularization, Stroke
< Back to Listings
