Study Shows Patients Undergoing PCI in Sweden Grow Older, Sicker
The indication for PCI also changed over time. In the 1990-1995 cohort, the majority of patients (66.4 percent) underwent PCI for stable coronary artery disease, whereas the majority of patients in the 2009-2010 cohort presented with unstable coronary artery disease (47.7 percent) and STEMI (32.5 percent). There was also an increase in the prevalence of diabetes and hypertension, which the investigators attributed to the aging population.
Nevertheless, the study authors did note a decrease in mortality. While the crude one-year mortality rate increased from 2.2 percent in 1990-1995 to 5.9 percent in 2009-2010 (p<0.001), after adjustment for age and indication, there was a modest decrease in mortality risk over time that was mainly associated with a decrease in mortality among patients with STEMI.
Moving forward, the authors suggest that future trials should be designed to take into account the changing patient population.
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