CRT-D Provides Greater Long-Term Benefit Than ICD Alone
Cardiac resynchronization therapy with a defibrillator (CRT-D), as compared to implantable cardiac defibrillation (ICD) alone, is associated with significant reductions in the long-term risk of heart failure or death, according to findings presented Sept. 3 at the ESC Congress 2013 in Amsterdam.
Further, the long-term benefit of CRT-D was found to be evident in left bundle branch block (LBBB) patients (HR=0.45 [95 percent CI 0.32-0.64]), "with continued separation in event rates throughout follow-up, and non-significant among non-LBBB patients (HR=0.82 [95 percent CI 0.46-1.48]; p-value for treatment-by-LBBB interaction = 0.04)."
"Our findings indicate that the clinical and echocardiographic benefits of cardiac resynchronization therapy in MADIT-CRT were sustained over an extended median follow-up period of > 6 years," wrote the authors. However, "the long-term benefit of cardiac resynchronization therapy in this population appears to be restricted to LBBB patients," they add.
Clinical Topics: Arrhythmias and Clinical EP, Heart Failure and Cardiomyopathies, Noninvasive Imaging, Implantable Devices, EP Basic Science, SCD/Ventricular Arrhythmias, Acute Heart Failure, Echocardiography/Ultrasound
Keywords: Follow-Up Studies, Electric Countershock, Heart Failure, Bundle-Branch Block, Defibrillators, Implantable, Cardiac Resynchronization Therapy, Echocardiography
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