Does Aspirin Intake at Bedtime Decrease BP and Morning Peak of Platelet Reactivity?

The timing of aspirin administration may result in a reduced risk of cardiovascular events, according to the Aspirin in Reduction of Tension II trial, presented Nov. 19 as part of AHA 2013.

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The study looked at 290 patients taking aspirin for secondary prevention of cardiovascular events who were randomized to 100 mg aspirin on awakening or at bedtime during two three-month periods. At the conclusion of each three-month study period, 24-hour blood pressure was recorded and platelet reactivity measured using the VerifyNow® Aspirin assay.

Results showed that taking aspirin at bedtime instead of in the morning did not impact blood pressure, and blood pressure reductions were not associated with the timing of aspirin administration. However, bedtime aspirin administration was associated with a 22-point decrease in aspirin reaction units.

The authors note that "bedtime aspirin intake might possibly reduce excess of acute cardiovascular events during the morning hours," but future studies are needed to verify clinical endpoints.

Clinical Topics: Prevention, Hypertension

Keywords: Secondary Prevention, Risk Reduction Behavior, Blood Pressure, Blood Platelets, Hypertension


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