Top Clinical Trials

Deepak L. Bhatt, MD, MPH, FACC
Senior Associate Editor, Clinical Trials and News, ACC.org

This year's top 10 clinical trial summaries on ACC.org reflect the evolving science which is informing our use of anti-coagulants, anti-platelet agents, and new observations in interventional and structural heart disease. How fortunate we are in our field to have a steady pipeline of both new products and insights into their use informed by large multicenter and frequently multinational clinical trials! Let's hope 2018 brings even more insights!

— Deepak L. Bhatt, MD, MPH, FACC

• PIONEER AF-PCI: An Open-Label, Randomized, Controlled, Multicenter Study Exploring Two Treatment Strategies of Rivaroxaban and a Dose-Adjusted Oral Vitamin K Antagonist Treatment Strategy in Subjects With Atrial Fibrillation Who Undergo Percutaneous Coronary Intervention
• FOURIER: Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk
• EINSTEIN CHOICE: Reduced-Dosed Rivaroxaban in the Long-Term Prevention of Recurrent Symptomatic Venous Thromboembolism
• DAPT: Dual Anti-platelet Therapy
• GEMINI-ACS-1: Safety of Rivaroxaban Versus Acetylsalicylic Acid in Addition to Either Clopidogrel or Ticagrelor Therapy in Participants With Acute Coronary Syndrome
• DECISION-CTO: Optimal Medical Therapy With or Without Stenting For Coronary Chronic Total Occlusion
• HOPE-3: Heart Outcomes Prevention Evaluation–3
• SPRINT: Systolic Blood Pressure Intervention Trial
• ORBITA: Objective Randomised Blinded Investigation With Optimal Medical Therapy of Angioplasty in Stable Angina
• RESPECT: Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment

Top Journal Scans

Kim A. Eagle, MD, MACC
Editor-in-Chief, ACC.org

The year in ACC.org journal scans is highlighted by the popularity of our "Key Points to Remember" around guidelines, focused updates, and expert consensus pathway documents. As we become busier and busier in delivering cardiovascular care, it is more and more challenging to keep up with advances in care. Therefore, the journal scan format—with their Key Points—keep us updated with bite-sized information. The top journal scans in terms of readership include the recent guideline for high blood pressure, focused updates on the management of heart failure and valvular heart disease, and the ACC/AHA/HRS guideline for patients with syncope. Also featured are updated documents around STEMI, deep vein thrombosis, periprocedural management of anti-coagulation and the use of non-statin therapies.

— Kim A. Eagle, MD, MACC

• 2017 Guideline for High Blood Pressure in Adults
• 2017 ACC/AHA/HFSA Focused Update Guideline for the Management of Heart Failure
• 2017 AHA/ACC Focused Update of Valvular Heart Disease Guideline
• 2017 ACC/AHA/HRS Guideline for Patients With Syncope
• 2017 ESC Guidelines for the Management of STEMI
• Diagnosis and Management of Acute Deep Vein Thrombosis
• ACC Decision Pathway for Periprocedural Anti-coagulation
• 2017 ACC Recommendations for Non-Statin Therapy
• ACC Expert Consensus on TAVR for Adults With Aortic Stenosis
• Appropriate Use Criteria for Coronary Revascularization in Stable Ischemic Heart Disease

Keywords: Acute Coronary Syndrome, Anticoagulants, Arrhythmias, Cardiac, Cardiac Surgical Procedures, Metabolic Syndrome, Angina, Stable, Heart Defects, Congenital, Dyslipidemias, Geriatrics, Heart Failure, Angiography, Diagnostic Imaging, Pericarditis, Secondary Prevention, Hypertension, Pulmonary, Sleep Apnea Syndromes, Sports, Aneurysm

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