Principal Findings:

Predictors of first MI: The incidence of first myocardial infarction at average of 4.8 years follow-up was higher in men (20.7 per 1000 person-years) than women (7.9 per 1000 person-years). The incidence was strongly associated with age, increasing from 7.8 to 25.6 per 1000 person-years in subjects age 65-69 years vs >=85 years. Glucose level and systolic blood pressure were associated with the incidence of MI, but smoking and lipid measures were not. After adjustment for age and sex, the significant subclinical disease predictors of MI were borderline or abnormal ejection fraction by echocardiography, high levels of intimal-medial thickness of the internal carotid artery, and a low ankle-arm index. Predictors of development of CHF: During an average follow-up of 5.5 years, the incidence of development of CHF was 19.3/1,000 person-years. The incidence of CHF increased progressively across age groups and was greater in men than in women. On multivariate analysis, other independent predictors included prevalent coronary heart disease, stroke or transient ischemic attack at baseline, diabetes, systolic blood pressure, forced expiratory volume 1 s, creatinine >1.4 mg/dl, CRP, ankle-arm index <0.9, atrial fibrillation, ECG left ventricular mass, ECG ST-T segment abnormality, internal carotid artery wall thickness and decreased LV systolic function.