Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy - CREATE


The goal of the trial was to evaluate interpersonal psychotherapy (IPT) compared with clinical management, and to evaluate the selective serotonin reuptake inhibitor (SSRI) citalopram with placebo in a 2 x 2 factorial design among patients with coronary artery disease (CAD) and major depression.