Proton Pump Inhibitors And Clopidogrel Association - PACA

Description:

Clopidogrel has been shown to have a broad variability in its response, partly related to the activity of the CYP450 system, specifically the isoform 2C19. A number of proton pump inhibitors (PPIs) are also metabolized by the same system, and so a few small studies have indicated that PPIs may attenuate the antiplatelet efficacy of clopidogrel. The PACA trial sought to assess the relative influences of omeprazole and pantoprazole on the antiplatelet efficacy of high-dose clopidogrel in patients ...