A Comparison of Recombinant Urokinase With Vascular Surgery as Initial Treatment for Acute Arterial Occlusion of the Legs - TOPAS


The Thrombolysis or Peripheral Arterial Surgery (TOPAS) trial was a randomized, multicenter study designed to compare the efficacy and safety of catheter-administered urokinase and conventional open surgery as initial treatment in patients with acute peripheral arterial occlusion threatening the viability of the leg.