Study Design

Patients Enrolled: 305
Mean Follow Up: Six months
Mean Patient Age: Mean age 80 ± 3.7 years
Female: 43

Patient Populations:

Age 75 years or older with chest pain refractory to at least two antianginal drugs

Exclusions:

Acute MI within the previous 10 days; concomitant valvular or other heart disease; predominant congestive heart failure; life-limiting comorbid disease such as cancer or severe renal failure; unwillingness to undergo revascularization or impossibility of revascularization; and impossibility of increasing or optimizing medical therapy

Primary Endpoints:

Quality of life assessed by the questionnaire, and by the composite outcome of death, documented nonfatal myocardial infarction (MI), and hospital admission for increasing or unstable angina (acute coronary syndrome) with or without the need for revascularization after six months

Drug/Procedures Used:

Eligible patients were randomized to an invasive approach consisting of coronary angiography followed by percutaneous coronary intervention or coronary artery bypass graft if feasible, or an optimal medical approach in which patients received antianginal medications that were increased in number and dose to achieve as much pain relief as possible.