Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico–Heart Failure: n-3 PUFA - GISSI-HF: n-3 PUFA Study


Although there are some laboratory and epidemiological data that suggest a beneficial effect of n-3 polyunsaturated fatty acids (PUFA) on ventricular function and sudden cardiac death, this has not been well studied in the setting of a randomized controlled trial. Accordingly, the GISSI-HF trial sought to study the efficacy of n-3 PUFA on mortality and morbidity in patients with symptomatic heart failure.