Clopidogrel and the Optimization of Gastrointestinal Events Trial - COGENT

Description:

A few platelet studies have indicated that proton pump inhibitors (PPIs), specifically omeprazole, are associated with reduced antiplatelet efficacy of clopidogrel, when used together. In addition, the use of dual antiplatelet therapy is often fraught with problems of gastrointestinal (GI) bleeding in patients at higher risk for bleeding. The current trial sought to study clinical GI and cardiovascular (CV) outcomes in patients on dual antiplatelet therapy with aspirin and clopidogrel, wh...