Diuretic Optimization Strategies Evaluation in Acute Heart Failure - DOSE


Although intravenous (IV) diuretics are routinely used in clinical practice, the optimal dosage and route of administration are not well understood. In addition, observational studies have demonstrated worsening creatinine and clinical outcomes with higher dose of furosemide. Accordingly, the DOSE study sought to evaluate the safety and efficacy of different strategies for diuretic dosing in patients with acute decompensated heart failure (ADHF).