Placebo-Controlled Randomized Study of the Selective A1 Adenosine Receptor Antagonist Rolofylline for Patients Hospitalized With Acute Decompensated Heart Failure and Volume Overload to Assess Treatment Effect on Congestion and Renal Function - PROTECT (rolofylline vs. placebo)


The goal of the trial was to evaluate the efficacy and safety of rolofylline, a selective adenosine A1-receptor antagonist, compared with placebo, among patients with acute heart failure and impaired renal function.