A Prospective, Randomized Trial of Transapical Transcatheter Aortic Valve Implantation vs. Surgical Aortic Valve Replacement in Operable Elderly Patients With Aortic Stenosis - STACCATO


The landmark PARTNER trial demonstrated the superiority of transcatheter aortic valve replacement (TAVR) over medical therapy in patients with inoperable severe aortic stenosis (cohort B), and the noninferiority of TAVR as compared with surgical AVR in patients who were at high risk for surgery (Society of Thoracic Surgeons [STS] score ≥8%) (cohort A).

The current trial sought to compare outcomes after transapical TAVR as compared with surgical AVR in elderly patients with severe aor...