Randomized and Clinical Effectiveness Trial Comparing Two Pharmacogenetic Algorithms and Standard Care for Individualizing Warfarin Dosing - CoumaGen-II

Description:

Warfarin is a commonly prescribed medication that has a narrow therapeutic range, with marked interpatient variability in PK and PD. Pharmacogenetic (PG) studies have identified two genes, CYP2C9 (cytochrome p450 isoform) and VKORC1 (vitamin K epoxide reductase complex subunit 1), to consistently determine warfarin dose requirements. However, studies incorporating genotype analysis and tailored therapy have been inconsistent. The current trial sought to study the safety and eff...