Third International Study on Syncope of Uncertain Etiology - ISSUE 3

Description:

Data on permanent pacing in patients with neurally mediated syncope (NMS) have been discouraging. For example, in ISSUE-2, there was no impact of pacing in unselected patients with NMS. However, on subgroup analysis, patients with asystolic NMS did demonstrate a significant reduction in recurrent syncope with pacing. The current trial sought to systematically study if patients with NMS and documented asystole on implantable loop recording would benefit from permanent pacemaker (PPM) impla...