Percutaneous Closure of Patent Foramen Ovale Versus Medical Treatment in Patients With Cryptogenic Embolism - PC

Description:

Numerous observational studies have suggested a beneficial effect of patent foramen ovale (PFO) closure on recurrent stroke in patients with cryptogenic stroke and PFO. However, the only randomized controlled trial on this topic, CLOSURE I, failed to show a benefit with PFO closure using the STARFlex device over routine medical management with anticoagulant/antiplatelet agents. The PC trial sought to compare outcomes after PFO closure with the Amplatzer PFO Occluder over medical therapy i...