A Novel Family-Based Intervention Trial to Improve Heart Health - FIT Heart
The goal of the trial was to evaluate the family members of a hospitalized cardiac patient and to identify and modify their cardiovascular risk factors.
Risk factor modification among family members would be more effective in reducing low-density lipoprotein (LDL) cholesterol.
Patients Screened: 3,649
Patients Enrolled: 501
Mean Follow Up: 1 year
Mean Patient Age: Mean 48 years; 12% >65 years
- Family members or co-habitants of a hospitalized cardiac patient
- Ages 20-79 years
- Residence within 3 hours of the hospital
- Known diabetes, cardiovascular, liver, or renal disease
- Current or planned pregnancy
- Limited life expectancy
- Prescription of a special diet
- Participation in another clinical study within the last 3 months
- Another family member is enrolled in the trial
- Percent change in LDL cholesterol
- Change in diet/lifestyle
- Change in other cardiovascular risk factors
Patients were randomized to special intervention (n = 250) vs. control (n = 251).
Overall, 501 patients were randomized. Among the special intervention group, there were 66% women and 32% had a body mass index (BMI) ≥30 kg/m2.
At 1 year, the percent change in LDL cholesterol was -1.0% in the intervention group vs. -2.0% in the control group (p = NS). Within the groups, LDL declined significantly over follow-up; -4.4 mg/dl in the intervention group (p = 0.03) and -4.5 mg/dl in the control group (p = 0.005).
At 1 year, for intervention vs. control, high-density lipoprotein (HDL) cholesterol was 58.7 mg/dl vs. 57.6 mg/dl (p = 0.01), systolic blood pressure was 130 mm Hg vs. 130 mm Hg (p = 0.90), and BMI was 27.7 kg/m2 vs. 28.4 kg/m2 (p = 0.88).
Among family members of a hospitalized cardiac patient, a special intervention program designed to more comprehensively identify and modify cardiac risk factors is not more effective than a control program in lowering LDL cholesterol. The special intervention group was associated with a slightly higher HDL cholesterol at follow-up.
Mosca L, Mochari H, Liao M, et al. A novel family-based intervention trial to improve heart health: FIT Heart. Circ Cardiovasc Qual Outcomes 2008;1:98-106.
Presented by Dr. Lori Mosca at the American Heart Association Annual Scientific Sessions, New Orleans, November 2008.
Keywords: Coronary Artery Disease, Behavior Therapy, Follow-Up Studies, Body Mass Index, Cholesterol, LDL, Hyperlipidemias, Risk Factors, Cholesterol, HDL, Hypercholesterolemia, Hypertension
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