Simvastatin and Ezetimibe in Aortic Stenosis - SEAS


Some preliminary data suggest that statin therapy may have a beneficial effect on calcific aortic stenosis (AS). Accordingly, the goal of SEAS, a double-blind, randomized controlled trial, was to investigate whether aggressive lipid lowering with ezetimibe/simvastatin 10/40 mg daily in asymptomatic moderate AS patients is associated with improved cardiovascular outcomes, compared with placebo.