Increased Mortality After Dronedarone Therapy for Severe Heart Failure - ANDROMEDA


Patients with heart failure have higher mortality and morbidity with atrial and ventricular arrhythmias. Dronedarone, a newer antiarrhythmic drug, is similar to amiodarone, and has been shown to be efficacious in the treatment of atrial fibrillation (AF), without an observed proarrhythmic effect. Accordingly, the goal of this trial was to evaluate the efficacy of dronedarone in reducing hospitalization due to congestive heart failure (CHF) in patients with symptomatic heart failure.