Prospective Randomized On-X Anticoagulation Clinical Trial: Reduced Anticoagulation for a Mechanical Heart Valve - PROACT

Description:

Current guidelines recommend an international normalized ratio (INR) goal of 2-3 in patients with bileaflet mechanical or Medtronic Hall valves (2.5-3.5 if risk factors are present). On-X is a new pure carbon valve with a different design, as compared with currently available valves. The current trial was a Food and Drug Administration investigational device exemption (FDA IDE) trial to study the safety and efficacy of lower dose anticoagulation in patients who underwent valve replacement...