Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist - TOPCAT


Mineralocorticoid receptor antagonists have been shown to reduce the risk of death and other major cardiovascular (CV) events in patients with reduced ejection fraction (EF) heart failure (HF) and following myocardial infarction. The current trial sought to study the safety and efficacy of spironolactone in patients with HF with preserved EF (HFpEF).