Four-Factor Prothrombin Complex Concentrate vs. Plasma for Rapid Vitamin K Antagonist Reversal in Patients Needing Urgent Surgical or Invasive Interventions - 4F-PCC vs. Plasma


The goal of the trial was to evaluate four-factor prothrombin complex concentrate (4F-PCC) compared with plasma among patients receiving a vitamin K antagonist and needing an urgent surgical procedure.

Contribution to the Literature: The 4F-PCC vs. Plasma trial showed that 4F-PCC was superior to plasma at achieving effective hemostasis and rapid INR reversal.