Basel Kosten Effektivitäts Trial – SAphenous Venous Graft Angioplasty Using Glycoprotein 2b/3a Receptor Inhibitors and Drug-Eluting Stents - BASKET-SAVAGE

Contribution To Literature:

The BASKET-SAVAGE trial showed that drug-eluting stents reduce major adverse cardiac events in saphenous vein graft lesions.


The goal of the trial was to evaluate percutaneous coronary intervention (PCI) with a drug-eluting stent compared with a bare-metal stent among patients with a saphenous vein graft (SVG) lesion.

Study Design

  • Randomized
  • Parallel

Patients with a saphenous vein graft (SVG) lesion were randomized to a drug-eluting stent (Taxus Liberte; n = 89) versus a bare-metal stent (Liberte; n = 84). All patients were recommended to receive a glycoprotein IIb/IIIa inhibitor and a distal protection device (FilterWire) during PCI.

Inclusion criteria:

  • Patients with SVG stenosis undergoing PCI
  • Total number of enrollees: 173
  • Duration of follow-up: 36 months
  • Mean patient age: 72 years

The trial was terminated early due to slow enrollment.

Principal Findings:

The primary outcome, incidence of cardiac death, nonfatal myocardial infarction, or target vessel revascularization at 12 months, occurred in 2.3% of the drug-eluting stent group versus 17.9% of the bare-metal stent group (p < 0.001). The association remained the same in longer-term follow-up.

Secondary outcomes:

  • Stent thrombosis: 0 versus 4.8% (p = 0.09); respectively, for drug-eluting versus bare-metal stents
  • Major bleeding: 2.3% versus 2.4% (p = 0.91); respectively, for drug-eluting versus bare-metal stents


Among patients with a SVG lesion, the use of a drug-eluting stent was associated with a reduction in major adverse events compared with a bare-metal stent. The risk of stent thrombosis and major bleeding were the same between treatment groups. The results of the DIVA trial are awaited.


Presented by Dr. Raban Jeger at the European Society of Cardiology Congress, Rome, Italy, August 30, 2016.

Clinical Topics: Acute Coronary Syndromes, Invasive Cardiovascular Angiography and Intervention, Interventions and ACS

Keywords: Acute Coronary Syndrome, Angina Pectoris, Constriction, Pathologic, Drug-Eluting Stents, Hemorrhage, Myocardial Infarction, Percutaneous Coronary Intervention, Platelet Glycoprotein GPIIb-IIIa Complex, Saphenous Vein, Stents, Thrombosis, ESC Congress

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