Multicenter Study of MagLev Technology in Patients Undergoing Mechanical Circulatory Therapy With HeartMate 3 - MOMENTUM 3
Contribution To Literature:
The MOMENTUM 3 trial showed that a centrifugal-flow LVAD was superior at preventing pump thrombosis.
The goal of the trial was to evaluate treatment with a magnetically levitated centrifugal-flow left ventricular assist device (LVAD) compared with an axial-flow LVAD among heart failure patients requiring advanced mechanical support. The centrifugal-flow LVAD was designed to prevent pump thrombosis.
Patients with advanced heart failure were randomized to a centrifugal-flow pump (n = 152) versus an axial-flow pump (n = 142).
- Total number of enrollees: 294
- Duration of follow-up: 6 months
- Median patient age: 63 years
- Percentage female: 20%
- Patients with advanced heart failure requiring LVAD
- Patients requiring bridge or destination therapy were eligible
- Planned biventricular support
- Irreversible end-organ dysfunction
- Active infection
The primary outcome, freedom from disabling stroke or reoperation to replace/remove the device at 6 months, occurred in 86.2% of the centrifugal-flow pump group versus 76.8% of the axial-flow pump group (p < 0.001 for noninferiority; p = 0.04 for superiority).
- Reoperation for pump malfunction: 0.7% versus 7.7% (p = 0.002); respectively, for centrifugal versus axial pump
- Pump thrombosis: 0% versus 10.1%; respectively, for centrifugal versus axial pump
Among patients with heart failure requiring advanced mechanical support, a centrifugal-flow LVAD was associated with better outcomes compared with an axial-flow LVAD. Benefit was primarily due to a reduction in pump malfunction and pump thrombosis.
Mehra MR, Naka Y, Uriel N, et al., on behalf of the MOMENTUM 3 Investigators. A fully magnetically levitated circulatory pump for advanced heart failure. N Engl J Med 2016;Nov 16:[Epub ahead of print].
Presented by Dr. Mandeep R. Mehra at the American Heart Association Annual Scientific Sessions (AHA 2016), New Orleans, LA, November 16, 2016.
Clinical Topics: Cardiac Surgery, Heart Failure and Cardiomyopathies, Invasive Cardiovascular Angiography and Intervention, Cardiac Surgery and Heart Failure, Acute Heart Failure, Mechanical Circulatory Support
Keywords: AHA Annual Scientific Sessions, Cardiac Surgical Procedures, Heart, Artificial, Heart Failure, Heart-Assist Devices, Reoperation, Thrombosis, Stroke
< Back to Listings