Albuminuria and Blood Pressure, Independent Targets for Cardioprotective Therapy in Patients With Diabetes and Nephropathy: A Post Hoc Analysis of the Combined RENAAL and IDNT Trials

Study Questions:

The long-term cardioprotective effect of angiotensin-receptor blockers (ARBs) is associated with the short-term lowering of its primary target blood pressure, but also with the lowering of albuminuria. How does the variability and discordance in systolic blood pressure (SBP) and albuminuria response to ARB therapy affect long-term cardiovascular (CV) outcomes?