Use of Varenicline for 4 Weeks Before Quitting Smoking: Decrease in Ad Lib Smoking and Increase in Smoking Cessation Rates

Study Questions:

The use of varenicline alleviates post-quit withdrawal discomfort, and reduces the “reward” associated with smoking. The current treatment schedule, which commences 1 week before quitting, relies primarily on the first mechanism. Does increasing the pre-quit medication period render cigarettes less satisfying and facilitate quitting?