Results:

There was no change in the blood pressure, or measures of LV mass or diastolic function in the control group. Among patients undergoing renal denervation, there was a clinically significant reduction in systolic (-22 mm Hg) and diastolic blood pressure (-7 mm Hg) at 1 month that was sustained at 6 months (-27/-8.8 mm Hg). There was a significant decrease in mean interventricular septum thickness from 14.1 ± 1.9 mm to 13.4 ± 2.1 mm (at 1 month) and 12.5 ± 1.4 mm (p = 0.007) at 6 months. The LV mass index decreased from 53.9 ± 15.6 g/m^2.7 to 47.0 ± 14.2 g/m^2.7 at 1 month and 44.7 ± 14.9 g/m^2.7 at 6 months (p < 0.001). An improvement in filling pressures was seen, with the mitral valve lateral E/E’ decreasing from 9.9 ± 4 to 7.9 ± 2.2 at 1 month and 7.4 ± 2.7 at 6 months (p < 0.001). There was a corresponding reduction in isovolumic relaxation time (from 109 ms at baseline to 85 ms at 6 months) and an increase in ejection fraction (63% at baseline to 70% at 6 months).