Plasma HDL Cholesterol and Risk of Myocardial Infarction: A Mendelian Randomization Study

Study Questions:

High plasma high-density lipoprotein cholesterol (HDL-C) is associated with reduced risk of myocardial infarction (MI), but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of nongenetic confounding, and are unmodified by disease processes, mendelian randomization can be used to test the hypothesis that the association of a plasma biomarker with disease is causal. Is the genetic predisposition to a higher level of HDL-C associated with a lower risk of MI?