Comparison of Novel Risk Markers for Improvement in Cardiovascular Risk Assessment in Intermediate-Risk Individuals

Study Questions:

What is the relative improvement in prediction of incident coronary heart disease (CHD) and cardiovascular disease events (CVEs) by the Framingham Risk Score (FRC) with the addition of other risk markers including coronary artery calcium (CAC), carotid intima–media thickness (CIMT), ankle-brachial index (ABI), brachial flow–mediated dilation, high-sensitivity C-reactive protein (CRP), and family history of CHD within intermediate-risk participants (FRS <5%-<20%) in the MESA (Multi-Ethnic Study of Atherosclerosis) study?